You are here: Home Research
Document Actions

Research Overview


The construction and cleavage of C-C, C-Het (Het = heteroatom), and Het-Het bonds are at the heart of organic, polymer, biological, and medicinal chemistry. The research in the Streuff group focuses on the development of unconventional methods for such bond formations and cleavages that are not accessible by conventional means. To achieve this, the group works at the interface of transition metal catalysis, organometallic chemistry, and physical organic chemistry to develop the envisioned methods, to design and synthesize new catalysts, and to understand the underlying complex mechanisms, respectively. Currently, we are working on four research lines, which are briefly outlined in the following.


1) Catalyst-Controlled Radical Reactions and Reductive Umpolung Reactions

As an illustrative example, we have realized an asymmetric titanium(III)-catalyzed reductive ketonitrile cyclization that gives α-hydroxyketones from readily available ketonitriles in high yield and enantioselectivity (see: Angew. Chem. 2012). The concept has been expanded to a series of other reductive umpolung reactions for the synthesis of α-aminoketones and pyrrolidinones, intermolecular cross-couplings, Michael-umpolung reactions, and sequential double-umpolung processes. We are currently further exploring this concept applying it in the synthesis of heterocycles and natural products. For more details, see our publications page.


2) Catalytic Single-Bond Cleavage Reactions


3) Design of Metallocene Catalysts


4) Elucidation of Complex Reaction Mechanisms

Personal tools